Healthy Lifestyles Are Associated with Reduced Mortality Risk… – In ASCO Post

By The ASCO Post Staff

Posted: 4/7/2023 10:58:00 AM

Last Updated: 4/7/2023 10:20:15 AM

Researchers have provided strong evidence that a healthy lifestyle significantly reduces mortality in adult pediatric cancer survivors; according to the new Dixon et al. Lance. The findings were among the first to show that the leading primary causes of mortality in long-term cancer survivors may include many of the same leading causes of mortality for people in the general population.


Treatments for pediatric cancers have improved to the point where over 85% of US patients successfully cure their first-line tumors after treatment. While more pediatric cancer patients are surviving, the number of adult survivors is growing.

The Childhood Cancer Survivor Study is the largest cohort of cancer survivors in North America, representing an estimate of all pediatric cancer survivors in that country.

Permission to survive Numerus

In a new report from the Childhood Cancer Survivor Study, researchers used more detailed health data on 1,000 participants to find statistically significant differences in the overall mortality rate of pediatric cancer survivors. They also show that when common confounders such as sociodemographic characteristics were controlled, the difference in mortality between survivors and the general population persisted, but the protective effect of a healthy lifestyle persisted.

The researchers found that adults who survived pediatric cancer had four times the risk of late mortality as the general population, even 40 years after diagnosis. However, the researchers also found that pediatric cancer survivors without certain modifiable risk factors and cardiovascular causes had a lower risk of mortality, suggesting that patients in this population may improve their chances of survival. Pediatric cancer survivors who define a healthy lifestyle as having a healthy weight, abstaining from drinking more than a moderate amount of alcohol and smoking, and exercising at or above the intensity recommended by the US Centers for Disease Control and Prevention to demonstrate 20 the lowest risk of mortality compared to those who followed the epidemic lifestyle.

“These findings provide important evidence that the high risk of mortality that people face can be reduced through changes in health behavior,” explained the senior author of the study. Greg Armstrong, MD, MSCE, Chair of the Department of Epidemiology and Cancer Control and Co-Director of the Cancer Control & Survivorship Program at St. Jude Children’s Research Hospital. “This is important because our goal is to extend the life span [pediatric cancer] survivors and to improve their health as well as space,” he continued.

In addition to modifiable lifestyle risk factors, researchers have identified several major risk factors for cardiovascular disease and related conditions that are associated with a greater risk of mortality among adult survivors of pediatric cancer. Patients with hypertension or diabetes had a significantly higher mortality than those without the conditions. However, cardiovascular risk factors were also modifiable.

“Much research has shown that survivors are vulnerable to early-onset disease and mortality,” the study’s lead author emphasized. Melissa Hudson, MD, Charles E. Williams Endowed Chair in Oncology-Cancer Survivorship, Director of the Division of Cancer Survivorship, and Co-Director of the Cancer Control & Survivorship Program at St. Jude Children’s Research Hospital. “The study highlights the importance of encouraging” [pediatric cancer] “remains to exercise healthy habits and maintain good control of cardiovascular diseases, risk factors to improve their health and life span,” he added.

Excess Mortality and Cause of Mortality in Pediatric Cancer Survivors

“We are identified as long-term survivors” [pediatric] “cancer experiences a large number of deaths in excess of what is expected for the general, aging population,” the study’s lead author underscored Stephanie Dixon, MD, MPHmember of the Assistant Department of Oncology as well as the Epidemiology and Cancer Control Divisions of Cancer Survivorship and Leukemia/Lymphoma at St. Jude Children’s Hospital. “[D]deaths after treatment, these excess deaths prevail from the same causes of death as in the general population, among secondary cancers; [cardiovascular] cerebrovascular disease/stroke, chronic liver and kidney disease, and infectious causes of death.[and are typically] experts at a younger age and more fertile in [pediatric] residual cancer” had highlighted.


“What was most exciting to see was that independent of prior treatment detection and sociodemographic factors, a healthy lifestyle and the absence of hypertension or diabetes, each was associated with a reduced risk. [cardiovascular-associated] mortality,” Dr. Dixon said. “This hints [although] With continued efforts to reduce treatment intensity while maintaining (or improving) 5-year survival, future research should also focus on modifiable lifestyle and cardiovascular risk interventions that can be specifically tailored to survivors with the goal of reducing chronic disease. development and extending the life span of the remains [pediatric] cancer.”

Patients who were treated with more intensive therapies continued to experience higher mortality rates than other cancer survivors. Many studies have focused on minimizing the loss of the therapy, but many of the residuals that are in the studies were treated before the improved technique was published. The findings showed that clinicians and researchers need to consider interventions that can reduce the risks for pediatric cancer survivors who were treated with aggressive therapies.

“The Childhood Cancer Survivors Study continues to provide important insights into the long-term outcomes of a growing number [pediatric patients] to cure cancer, “said the author of the study collaborators Leslie Robinson, PhD, Chair Emeritus of the Department of Epidemiology and Cancer Control at St. Jude Children’s Hospital. “The findings from the current analysis need to be further emphasized in order to increase our efforts to reduce acute, chronic and late treatment toxicities, especially those toxicities that may directly or indirectly result in premature mortality.”

Open: The research in this study was supported by grants from the National Cancer Institute, a St. Jude Children’s Research Hospital Cancer Center Support grant, and the Associated Syrian Lebanese American Charities. For full disclosure of the study authors, visit

The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc.

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Ava Grey

Hi there! I'm Ava Grey, an enthusiastic article writer with a passion for the arts, fashion, and staying informed about current events. As a journalism student at the New York Academy of Art, I'm driven to use my writing to create positive change and spark meaningful conversations. I'm particularly interested in contemporary art and sustainable fashion, and I love exploring how people use these mediums to express themselves and communicate their values. I believe that staying informed and hearing different perspectives is essential for personal growth and learning, and I'm always eager to engage in lively debates and discussions.

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