Diet/lifestyle development against biological aging: A female case series – Medical Xpress

Participants’ average biological age change analysis. * Significant difference with p-value <.05. Credit: old age (2023). DOI: 10.18632/aging.204602

A new research paper published in old ageentitled “Potential reversal of biological age in women following an 8-week methylation-assisted diet and lifestyle program: a case series.”

In this new study, researchers Kara N. Fitzgerald, Tish Campbell, Suzanne Makarem, and Romilly Hodges from the Institute of Medical Services, Virginia State University and the Nutrition Association reported a series of six women who completed a methylation-supportive diet. and lifestyle programs to impact DNA methylation and biological measures of aging.

“The modifiable lifestyle intervention used by the participants in this case series was first investigated in a pilot clinical trial in which the participants (all men between the ages of 50-72 years) reduced their biological age by an average of 3.23 years, compared to controls. [7]. The series of cases reported on this led to further investigation of a modifiable lifestyle intervention, which is generally the same in other countries; significantly in women,” write the researchers.

The intervention group consisted of an eight-week program. This program includes guidance on diet, sleep, exercise, and relaxation, probiotic and phytonutrient supplements, and nutritional counseling. DNA methylation and biological age analysis (Horvath DNAmAge clock (2013), normalized using the seSAMe pipeline [a]) blood samples were taken at baseline and at the end of the eight-week period.

Five of the six participants showed a biological age reduction of between 1.22 and 11.01 years from the baseline biological age. Statistically significant (p=.039) difference in the participants’ mean biological age before (55.83 years) and after (51.23 years) the 8-week intervention and diet and lifestyle, with an average decrease of 4.60 years.

The average chronological age at the beginning of the program was 57.9 years and all but one participant had a biological age younger than the chronological age at the beginning of the program, suggesting that biological changes are unrelated to age and may be attributed to disease improvement instead. underlying aging mechanisms.

“This case series of female participants extends the previous pilot study of this intervention in men, indicating that biological second shifts in age can be achieved in both sexes. In addition, research suggests that people with different health than those diagnosed with disease directly influence aging mechanisms for disease-driven aging, researchers to conclude

More information:
Kara N. Fitzgerald et al, Potential reversal of biological age following an 8-week methylation-based diet and lifestyle program: a case series; old age (2023). DOI: 10.18632/aging.204602

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quote: Diet / lifestyle biological program of adverse age: A female case series (2023, April 3) Retrieved April 3, 2023 from

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